The Conference, slated for November 28–29, 2025, is conceived as a pivotal, transdisciplinary forum poised to convene distinguished scientists, pioneering researchers, academic leaders, industry innovators, and emerging scholars. Its core objectives are to facilitate the exchange of transformative ideas and to showcase frontier research within the dynamically evolving domain of computational sciences. With an emphasis on recent disruptions and paradigm-shifting developments, the conference will provide a platform for rigorous scholarly discourse and cross-domain collaboration. The technical sessions will delve into a comprehensive array of advanced topics including Next-Generation Network Technologies and 6G Protocols, Trustworthy and Explainable AI, Quantum Computing and High-Performance Architectures, Edge–Cloud Synergies and Federated Learning, Intelligent Human–Computer Interaction, IoT and Autonomous Cyber-Physical Systems, Scalable Data Science and Predictive Analytics, Blockchain and Smart Contract Security, Zero-Trust Cybersecurity Models and Privacy-Enhancing Cryptographic Techniques, Contemporary Software Engineering and CI/CD Automation, as well as breakthroughs in Image Processing, Computer Vision, Natural Language Understanding, Data Mining, and Large-Scale Information Retrieval Systems.